Seminar

Molecular Sensing with Zwitterion-Embedded Molecularly Imprinted Mesoporous Organosilica

조회수 : 176 등록일 : 2020.11.17 09:24

일시 : 2020.11.18 17:00
소속 : KIST EUROPE
발표자 : 이재호
장소 : R 1314/ ZOOM
During the past decades, detection of analytes with molecular imprinted polymer system and various imprinting methods have been developed. However, it has proven difficult to probe target molecules with high selectivity. To overcome this barrier, we introduce a general preparation method of zwitterion-embedded molecularly imprinted mesoporous organosilica (MIMO-z) by simple addition of zwitterionic precursors into conventional sol-gel reaction with target compounds. Quantum dots/ are encapsulated as a signal transducer to produce the optical probe (MIMO-zQ). The prepared MIMO-zQs show extraordinary emission intensity changes depending on concentration with high sensitivity of sub-nM in aqueous solution. Relative quenching values are plotted as dose-response curves expressed by logarithmic values of concentrations rather than general Stern-Volmer relationships. The results from the detection of glyphosate (a herbicide), and 3-nitro-L-tyrosine (an oxidative stress biomarker) will be presented in the lecture.
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