Chemical Dynamics in Living Cells |
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ÀϽà : 2019.09.25 17:00 |
¼Ò¼Ó : Áß¾Ó´ë ÈÇаú |
¹ßÇ¥ÀÚ : ¼ºÀ翵 |
Àå¼Ò : R404 |
We introduce a new type of kinetic model and theory
for biological networks, useful for a quantitative description of chemical
dynamics in living cells. One advantage of our approach is its applicability to
networks producing biomolecules with arbitrary lifetime distributions to which
the conventional approaches, such as the classical chemical kinetics, chemical
master equation, and chemical Langevin equation, are not applicable. Our
approach also enables quantitative investigation into biological networks composed
of multi-step or multi-channel reactions whose rates may fluctuate due to their
coupling to cell environments. We demonstrate these advantages by providing an
unprecedented quantitative explanation of non-classical chemical dynamics
observed in various biological systems including single enzymes [1], in vivo motor-protein multiplexes [2],
and cell systems with various synthetic gene networks [3]. Time-permitting, we
will also introduce a new transport equation governing thermal motion of
biomolecules in living cells [4]. |